An open knowledge graph linking trials, results, biomarkers, drugs and recommendations
Build a public, machine-readable map connecting every cancer trial to its results, the drugs and biomarkers involved, and the guideline recommendations it supports, with a source for every link.
Evidence in oncology is scattered across registries, papers, labels and guidelines with no shared identifiers. An open knowledge graph (trial identifiers, PICO elements, structured results, drug and biomarker ontologies, guideline recommendations, provenance for each edge) would let software answer 'what is the evidence for drug X in population Y' reproducibly. OncoKB, CIViC, Open Targets and ClinicalTrials.gov are partial graphs; the proposal funds their federation under open licences with a governance body and curation incentives.
- Knowledge reaches practice too slowly · Knowledge diffusion is slow: it takes years for a proven result to change what most patients receive, and no one can keep up with the literature.
- Data silos · Records, scans, genomes and outcomes sit in separate systems that cannot talk. Every patient's experience is lost to the next.
Pages like this
not linked directly; found by shared links- IdeaA tumour board assistant that cites its evidence and tracks outcomes
Shares Decision support that cites the exact trial and guideline line it relies on, OncoKB, Knowledge reaches practice too slowly.
- IdeaLabel every biomarker claim with an evidence phase, like drugs
Shares CIViC, OncoKB, Knowledge reaches practice too slowly.
- IdeaEvery tumour sequencing report lists open, nearby, matched trials pulled live
Shares CIViC, OncoKB, ClinicalTrials.gov, Knowledge reaches practice too slowly.
- TechnologyCancer variant knowledgebases and molecular tumour boards
- IdeaA randomised trial of AI-generated treatment recommendations versus tumour boards
Shares Decision support that cites the exact trial and guideline line it relies on, Knowledge reaches practice too slowly.
- IdeaLiving guidelines published as versioned, computable rules
Shares A public API serving the current standard of care for any cancer, stage and biomarker, Decision support that cites the exact trial and guideline line it relies on, Knowledge reaches practice too slowly.
- IdeaEvery tumour genomic report machine-readable and deposited nationally
Shares CIViC, OncoKB, Data silos.
- InstitutionEMBL's European Bioinformatics Institute
Shares Open Targets Platform, Knowledge reaches practice too slowly, Data silos.