Cancer variant knowledgebases and molecular tumour boards
Curated databases that say what each mutation means for treatment, and the expert meetings that use them to decide on therapy.
OncoKB (MSK; FDA-recognised), CIViC (WashU; open, crowd-curated), My Cancer Genome (Vanderbilt), JAX-CKB, COSMIC (Sanger), ClinVar, and cBioPortal supply the evidence layer for precision oncology; molecular tumour boards (institutional, national such as the UK's Genomic MDTs, and virtual services from Roche NAVIFY, Syapse, and Tempus) apply it to patients. Studies show actionable findings in 30-50% of sequenced patients but treatment uptake of only 10-25%, pointing to access and evidence gaps.
How it works
Expert curation of gene-variant-disease-drug evidence into levels (e.g. OncoKB 1-4, R1-R2), exposed by API for lab reporting and decision support.
- Open, citable evidence
- Regulatory recognition (OncoKB)
- Curation lag and disagreement between sources
- Sparse evidence for rare variants
- Tumour-board capacity
Latest papers
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