Warburg effect
Cancer cells burn glucose into lactate even when oxygen is plentiful, an inefficient but fast way to make building blocks. Otto Warburg described it in the 1920s.
Aerobic glycolysis driven by oncogenic signalling and HIF; supplies glycolytic intermediates for nucleotide, lipid, and amino-acid synthesis and acidifies the microenvironment. Basis of FDG PET.
Pages like this
not linked directly; found by shared links- TechnologyMetabolic therapy: starving the tumour of a nutrient
Shares ERGO2: ketogenic diet and fasting during re-irradiation of recurrent glioma, Warburg-effect diet claims ('sugar feeds cancer'), One definitive ketogenic diet trial in glioblastoma, then stop, Ketogenic diets in glioblastoma.
- PathwayKEAP1–NRF2 antioxidant pathway
Shares Hallmark: reprogramming cellular metabolism, Glutamine addiction, Cancer metabolism.
- IdeaDe-acidify the tumour so T cells can work in it
Shares Standardised uptake value (SUV), FDG PET.
- TermUnproven diet claims (alkaline, juice, 'anti-cancer' diets)
Shares Warburg-effect diet claims ('sugar feeds cancer'), One definitive ketogenic diet trial in glioblastoma, then stop, Ketogenic diets in glioblastoma.
- TechnologyFasting and fasting-mimicking diets around chemotherapy
Shares Warburg-effect diet claims ('sugar feeds cancer'), Nutrient competition & metabolic immunosuppression.
- TermGlycaemic index and glycaemic load
Shares Warburg-effect diet claims ('sugar feeds cancer'), Ketogenic diets in glioblastoma.
- IdeaAsk about diet at diagnosis, and prebunk the myths before the internet does
Shares Warburg-effect diet claims ('sugar feeds cancer'), Ketogenic diets in glioblastoma.
- IdeaMap metabolic dependencies in the patient, not the dish
Shares Cancer metabolism, FDG PET.