Variant of uncertain significance (VUS)
A variant of uncertain significance (VUS) is a genetic change that has been found but nobody yet knows whether it matters.
Common in germline panels (up to 30% of reports) and tumour sequencing. Should not drive treatment decisions; reclassified over time via ClinVar, functional assays, and population data.
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not linked directly; found by shared links- TermGermline vs somatic mutations
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- PersonGilda Radner
Shares Hereditary cancer syndromes, Inherited risk is mostly unidentified, Germline (hereditary) testing.
- InstitutionA.C. Camargo Cancer Center
Shares Hereditary cancer syndromes, Germline (hereditary) testing, Comprehensive genomic profiling.
- TermNext-generation sequencing (NGS)
Shares Every pathology and genomic report ships with a signed plain-language version, Genomic profiling, Comprehensive genomic profiling.
- PersonMary-Claire King
Shares Hereditary cancer syndromes, Inherited risk is mostly unidentified, Germline (hereditary) testing.
- IdeaUniversal tumour and germline sequencing at diagnosis feeding a shared learning system
Shares Inherited risk is mostly unidentified, Germline (hereditary) testing, Comprehensive genomic profiling.
- TermDriver mutation
Shares Mutation, Genomic profiling.