MEN1 and hereditary neuroendocrine syndromes
Inherited conditions (MEN1, VHL, NF1, tuberous sclerosis) that cause neuroendocrine tumours, often multiple and at a young age, so families need genetic testing and surveillance.
MEN1 (menin loss) causes parathyroid, pituitary and pancreatic NETs; MEN1 is also the most commonly mutated gene in sporadic pancreatic NETs (~40%), with DAXX/ATRX and mTOR-pathway genes. Germline testing is recommended for pancreatic NETs, paragangliomas (SDHx) and young-onset disease. Belzutifan is approved for VHL-associated pancreatic NETs.
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not linked directly; found by shared links- TermVon Hippel-Lindau disease
Shares Belzutifan, HIF-2α, Hereditary cancer syndromes, Neuroendocrine tumours.
- IdeaFamily history collected by app and matched to testing criteria automatically
Shares Inherited risk is mostly unidentified, Germline (hereditary) testing.
- TrialLITESPARK-022
Shares Belzutifan, HIF-2α.
- TrialLITESPARK-005
Shares Belzutifan, HIF-2α.
- IdeaBan life and disability insurers from using genetic results
Shares Inherited risk is mostly unidentified, Germline (hereditary) testing.
- IdeaBuild polygenic scores that work in every ancestry before deploying any
Shares Inherited risk is mostly unidentified, Germline (hereditary) testing.
- IdeaStore adult-onset cancer gene results from newborn genomes and disclose at 18
Shares Inherited risk is mostly unidentified, Germline (hereditary) testing.
- IdeaA chatbot for pre-test genetic counselling so counsellors see only who needs them
Shares Inherited risk is mostly unidentified, Germline (hereditary) testing.