AlphaMissense
Scored all 71 million possible single-letter protein changes in humans as likely harmful or benign.
Science 2023; classifications are widely used to triage variants of uncertain significance in cancer genes.
How it works
AlphaFold-derived model fine-tuned on population variant frequencies.
- Complete catalogue
- Pathogenicity is not the same as actionability
Latest papers
topQuery for this technology: (TITLE:"AlphaMissense" OR ABSTRACT:"AlphaMissense") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about AlphaMissense, not a curated reading list.
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