Driver mutation
One of the few mutations in a tumour that actually causes it to grow. Everything else is a passenger along for the ride. Drivers are the mutations drugs are aimed at.
A tumour with thousands of mutations usually has two to eight drivers that confer a growth advantage; the rest are passengers that happened to be present in the cell that became cancerous. Drivers cluster in a few hundred genes: oncogenes activated by mutation or amplification (EGFR, KRAS, BRAF, HER2, ALK) and tumour suppressors lost by mutation or deletion (TP53, RB1, PTEN). Genomic profiling looks for known drivers because a tumour that depends on one can often be treated with a drug against it, the phenomenon called oncogene addiction.
Pages like this
not linked directly; found by shared links- TermHallmark: sustaining proliferative signalling
Shares Oncogene, Oncogene addiction, ALK, BRAF.
- TermDeletion
Shares Mutation, Tumour suppressor gene, EGFR.
- TermGrowth signal
Shares Oncogene, Targeted therapy, BRAF, KRAS.
- TermKinase
Shares Oncogene, Targeted therapy, Oncogene addiction, ALK.
- TermGene
Shares Mutation, Oncogene, Tumour suppressor gene.
- PersonRyan B. Corcoran
- Key paperCancer genome landscapes: about 140 driver genes, and each tumour needs only a handful
Shares Oncogene addiction, BRAF, TP53, KRAS.
- PathwayDrivers, passengers & the two-hit model
Shares Oncogene addiction, ALK, BRAF, TP53.