Blood-brain barrier (BBB)
The tight seal around brain blood vessels that keeps most drugs out, one of the two main reasons brain cancer is so hard to treat.
Endothelial tight junctions, efflux transporters (P-gp, BCRP), and pericytes exclude most antibodies and many small molecules. Glioblastoma disrupts the barrier heterogeneously (contrast enhancement) but infiltrating cells sit behind intact barrier. Strategies: lipophilic/small brain-penetrant drugs (temozolomide, lomustine, dordaviprone, vorasidenib), locoregional delivery (CAR-T, convection-enhanced), focused-ultrasound opening, LITT, and intra-arterial delivery.
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not linked directly; found by shared links- ProductTemozolomide
Shares A skull ultrasound implant that opens the barrier at every cycle, CheckMate 548 & CheckMate 143 & CheckMate 498, Primary CNS lymphoma, The blood–brain barrier & brain metastasis.
- IdeaNeoadjuvant immunotherapy with surgical window for glioblastoma
Shares CheckMate 548 & CheckMate 143 & CheckMate 498, CAR-T for glioma (IL13Rα2, GD2, EGFRvIII, multi-target), The brain: barrier and sanctuary, Glioma & glioblastoma.
- CollectionNational Brain Tumor Society (NBTS)
Shares Dordaviprone, Primary CNS lymphoma, Medulloblastoma, Glioma & glioblastoma.
- TermH3 K27M (diffuse midline glioma)
Shares Dordaviprone, CAR-T for glioma (IL13Rα2, GD2, EGFRvIII, multi-target), The brain: barrier and sanctuary, Glioma & glioblastoma.
- IdeaOpen the barrier so engineered immune cells can enter the brain
Shares Focused-ultrasound blood-brain barrier opening, CAR-T for glioma (IL13Rα2, GD2, EGFRvIII, multi-target), The brain: barrier and sanctuary, Glioma & glioblastoma.
- CompanyInsightec
Shares Ultrasound-assisted blood test instead of a brain biopsy, Focused-ultrasound blood-brain barrier opening, The brain: barrier and sanctuary, Glioma & glioblastoma.
- PersonMichael Weller
Shares Lomustine (CCNU), Robot-placed catheters and live imaging for drug infusion into brain tumours, Glioma & glioblastoma.
- TechnologyMRI
Shares Laser interstitial thermal therapy (LITT), Robot-placed catheters and live imaging for drug infusion into brain tumours, Focused-ultrasound blood-brain barrier opening, Primary CNS lymphoma.