Lomustine (CCNU)
An old chemotherapy pill used when glioblastoma comes back, and the control arm most new glioblastoma drugs must beat.
Standard second-line agent in Europe and the control in EORTC 26101 (lomustine ± bevacizumab), REGOMA, and most recurrent-glioblastoma trials; median OS ~8-9 months at recurrence. CeTeG/NOA-09 suggested lomustine-temozolomide improves OS in MGMT-methylated newly diagnosed disease. Delayed, cumulative myelosuppression limits cycles.
Approvals
| Region | Year | Indication |
|---|---|---|
| US | 1976 | Brain tumours after surgery/radiation; Hodgkin lymphoma |
Trials
topRecruiting now (live from ClinicalTrials.gov)
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Latest papers
topQuery for this drug: (TITLE:"Lomustine" OR ABSTRACT:"Lomustine" OR TITLE:"CCNU" OR ABSTRACT:"CCNU" OR TITLE:"Gleostine" OR ABSTRACT:"Gleostine") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about Lomustine (CCNU), not a curated reading list.
Pages like this
not linked directly; found by shared links- TechnologyLaser interstitial thermal therapy (LITT)
Shares Blood-brain barrier (BBB), The blood–brain barrier & brain metastasis, Glioma & glioblastoma.
- IdeaRobot-placed catheters and live imaging for drug infusion into brain tumours
Shares Michael Weller, Blood-brain barrier (BBB), Glioma & glioblastoma.
- IdeaDeliver drugs and cells to the brain through the nose
Shares Blood-brain barrier (BBB), Cytotoxic chemotherapy, Glioma & glioblastoma.
- IdeaA skull ultrasound implant that opens the barrier at every cycle
Shares Blood-brain barrier (BBB), Cytotoxic chemotherapy, Glioma & glioblastoma.
- TrialEORTC 26981 / NCIC CE.3 (Stupp trial)
Shares Michael Weller, Glioma & glioblastoma.
- ProductTemozolomide
Shares Michael Weller, Base excision repair, PARP & alkylation damage, The blood–brain barrier & brain metastasis, Medulloblastoma.
- TermMGMT promoter methylation
Shares Base excision repair, PARP & alkylation damage, The blood–brain barrier & brain metastasis, Glioma & glioblastoma.
- InstitutionUniversity of Florida Health Cancer Center
Shares Medulloblastoma, Glioma & glioblastoma.