Allogeneic stem cell transplant (allo-SCT)
Replacing a patient's blood system with a donor's: chemotherapy wipes out the marrow, donor stem cells rebuild it, and the donor's immune cells hunt down leftover leukaemia. The only cure for many high-risk blood cancers, and the riskiest treatment in oncology.
Used for adverse-risk or relapsed AML, high-risk ALL and MDS, myelofibrosis and some lymphomas. Donors are HLA-matched siblings, matched unrelated donors from registries, haploidentical relatives (now safe with post-transplant cyclophosphamide) or cord blood. Conditioning is myeloablative or reduced-intensity depending on age and fitness. The graft-versus-leukaemia effect is the cure mechanism; graft-versus-host disease, infection and organ toxicity are the price, with treatment-related mortality of 10-25%. MRD-guided transplant decisions, CAR-T bridging and maintenance drugs after transplant (FLT3 inhibitors, azacitidine) are refining who needs it.
Pages like this
not linked directly; found by shared links- ProductBelumosudil
Shares Graft-versus-host disease (GVHD) and graft-versus-leukaemia, Acute lymphoblastic leukaemia, Acute myeloid leukaemia.
- TermInduction therapy
Shares 7+3 induction chemotherapy, Acute lymphoblastic leukaemia, Acute myeloid leukaemia.
- PersonStephen J. Forman
Shares Allogeneic (off-the-shelf) cell therapy, Acute lymphoblastic leukaemia, Acute myeloid leukaemia.
- TargetCD7
Shares Allogeneic (off-the-shelf) cell therapy, Acute lymphoblastic leukaemia, Acute myeloid leukaemia.
- InstitutionRamathibodi Hospital, Mahidol University
Shares Allogeneic (off-the-shelf) cell therapy, Acute lymphoblastic leukaemia, Acute myeloid leukaemia.
- ProductTreosulfan
Shares Conditioning regimen (myeloablative, reduced-intensity), Acute myeloid leukaemia.
- InstitutionMasonic Cancer Center, University of Minnesota
Shares Allogeneic (off-the-shelf) cell therapy, Acute lymphoblastic leukaemia, Acute myeloid leukaemia.
- InstitutionChristian Medical College, Vellore
Shares Allogeneic (off-the-shelf) cell therapy, Acute lymphoblastic leukaemia, Acute myeloid leukaemia.