Belumosudil
Belumosudil is a pill for chronic graft-versus-host disease, the long-term immune complication of donor stem-cell transplants used to cure blood cancers.
ROCKstar (2021): 74% overall response in cGVHD after ≥2 lines, including fibrotic organ involvement. Approved 2021 alongside ruxolitinib (REACH3) and ibrutinib; axatilimab (anti-CSF1R, 2024) followed. Part of the transplant survivorship toolkit.
- Medicare
- Part D (self-administered)
Oral, self-administered, so it is a Part D drug: covered through a stand-alone Part D plan or Medicare Advantage drug benefit, usually on the specialty tier with 25 to 33% coinsurance until the annual cap ($2,000 in 2025, $2,100 in 2026). Rezurock (chronic GVHD) is a Part D specialty drug.
- Commercial insurance
- covered with prior authorisation
Covered for FDA-labelled and NCCN-listed uses, but almost always behind prior authorisation confirming diagnosis, biomarker and line of therapy; dispensed through a specialty pharmacy. Plans require failure of at least two prior lines of systemic therapy for chronic GVHD, per the label.
- Assistance programmes
- Sanofi CareASSIST
- PAN Foundation — Disease-specific co-pay and premium funds; open and closed funds change monthly.
- HealthWell Foundation
- CancerCare Co-Payment Assistance Foundation
- Patient Advocate Foundation Co-Pay Relief
Part D out-of-pocket capped at $2,000 (2025) / $2,100 (2026). Medicare patients cannot use manufacturer co-pay cards; charity funds (PAN, HealthWell, CancerCare) and the Extra Help subsidy are the routes.
Sources: Medicare.gov: Drug coverage (Part D) · Medicare.gov: Costs for Medicare drug coverage (annual out-of-pocket cap). Not medical or financial advice; verify with your plan.
- Notes
- Chronic GVHD after 2 prior lines; MHRA-licensed 2023. NICE position not yet researched.
Sources: NICE search: belumosudil. Funding decisions are indication-specific and change monthly; verify with NICE and your treating team.
Approvals
| Region | Year | Indication |
|---|---|---|
| US | 2021 | Chronic GVHD after failure of ≥2 lines of systemic therapy (age ≥12) |
Trials
topRecruiting now (live from ClinicalTrials.gov)
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Latest papers
topQuery for this drug: (TITLE:"Belumosudil" OR ABSTRACT:"Belumosudil" OR TITLE:"Rezurock" OR ABSTRACT:"Rezurock") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about Belumosudil, not a curated reading list.