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Belumosudil

Belumosudil is a pill for chronic graft-versus-host disease, the long-term immune complication of donor stem-cell transplants used to cure blood cancers.

ROCKstar (2021): 74% overall response in cGVHD after ≥2 lines, including fibrotic organ involvement. Approved 2021 alongside ruxolitinib (REACH3) and ibrutinib; axatilimab (anti-CSF1R, 2024) followed. Part of the transplant survivorship toolkit.

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Belumosudil
PubChem
Modality
Oral ROCK2 inhibitor
Mechanism
Selective inhibition of Rho-associated coiled-coil kinase 2 rebalances Th17/Treg responses and reduces fibrosis in chronic graft-versus-host disease.
Brand / code
Rezurock
Medicare
Part D (self-administered)

Oral, self-administered, so it is a Part D drug: covered through a stand-alone Part D plan or Medicare Advantage drug benefit, usually on the specialty tier with 25 to 33% coinsurance until the annual cap ($2,000 in 2025, $2,100 in 2026). Rezurock (chronic GVHD) is a Part D specialty drug.

Commercial insurance
covered with prior authorisation

Covered for FDA-labelled and NCCN-listed uses, but almost always behind prior authorisation confirming diagnosis, biomarker and line of therapy; dispensed through a specialty pharmacy. Plans require failure of at least two prior lines of systemic therapy for chronic GVHD, per the label.

Assistance programmes

Part D out-of-pocket capped at $2,000 (2025) / $2,100 (2026). Medicare patients cannot use manufacturer co-pay cards; charity funds (PAN, HealthWell, CancerCare) and the Extra Help subsidy are the routes.

Sources: Medicare.gov: Drug coverage (Part D) · Medicare.gov: Costs for Medicare drug coverage (annual out-of-pocket cap). Not medical or financial advice; verify with your plan.

Not yet researchedSearch NICE
Notes
Chronic GVHD after 2 prior lines; MHRA-licensed 2023. NICE position not yet researched.

Sources: NICE search: belumosudil. Funding decisions are indication-specific and change monthly; verify with NICE and your treating team.

Regulatory

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Approvals

RegionYearIndication
US2021Chronic GVHD after failure of ≥2 lines of systemic therapy (age ≥12)

Trials

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Recruiting now (live from ClinicalTrials.gov)

Recruiting trials near you · live from ClinicalTrials.gov
Belumosudil
intervention: Belumosudil
Open on ClinicalTrials.gov →

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Latest papers

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Latest papers · live from Europe PMC
Open in Europe PMC

Query for this drug: (TITLE:"Belumosudil" OR ABSTRACT:"Belumosudil" OR TITLE:"Rezurock" OR ABSTRACT:"Rezurock") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about Belumosudil, not a curated reading list.

Connected

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