FLASH radiotherapy
Delivering an entire dose in under a second, which in animals spares healthy tissue while still killing the tumour.
Ultra-high dose rates (>40 Gy/s) reduce normal-tissue toxicity in preclinical models. First-in-human trials (FAST-01/02 with protons, Varian; electron trials in Lausanne) show feasibility. Mechanism (oxygen depletion, radical recombination) is debated and the clinical effect unproven.
How it works
Dose delivered in milliseconds rather than minutes; differential normal-tissue sparing.
- Potential to widen therapeutic window dramatically
- Unproven in humans
- Hardware constraints for deep tumours
Latest papers
topQuery for this technology: (TITLE:"FLASH radiotherapy" OR ABSTRACT:"FLASH radiotherapy" OR TITLE:"ultra-high dose rate radiotherapy" OR ABSTRACT:"ultra-high dose rate radiotherapy"). Results are unfiltered search hits about FLASH radiotherapy, not a curated reading list.
Pages like this
not linked directly; found by shared links- TechnologyProton arc therapy
Shares Varian (Siemens Healthineers) and the tag frontier.
- TechnologyPathology & radiology foundation models
Shares NCT/UCC Dresden – University Hospital Carl Gustav Carus and the tag frontier.
- TechnologyMR-guided adaptive radiotherapy
Shares A translation fund for academic surgical devices and radiotherapy technology, A regulatory pathway for new radiotherapy techniques modelled on drug development, Radiotherapy, American Society for Radiation Oncology.
- PersonMichael Baumann
Shares A regulatory pathway for new radiotherapy techniques modelled on drug development, NCT/UCC Dresden – University Hospital Carl Gustav Carus.
- IdeaCoverage-with-evidence registries for MR-guided and adaptive radiotherapy
Shares A regulatory pathway for new radiotherapy techniques modelled on drug development, Varian (Siemens Healthineers), Surgery and radiotherapy cure most, get least.
- TechnologyCarbon-ion therapy
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- CompanyIBA (Ion Beam Applications)
Shares Compact FLASH and proton systems at the price of a conventional linac, A coordinated FLASH radiotherapy evidence programme with shared dose-rate standards.
- TechnologyProton therapy
Shares Very-high-energy electron therapy, Compact FLASH and proton systems at the price of a conventional linac, A coordinated FLASH radiotherapy evidence programme with shared dose-rate standards, NCT/UCC Dresden – University Hospital Carl Gustav Carus.