OnCo
technologiesTechnologyPhase 1

Proton arc therapy

Rotating the proton beam continuously around the patient instead of firing from a few fixed angles, to spread the entrance dose and sharpen the target dose.

Proton arc delivers many low-weight spots from a continuously rotating gantry, improving conformality and robustness to range uncertainty. Vendors have released treatment-planning implementations and first patients have been reported at a small number of centres; a September 2026 search of ClinicalTrials.gov found no randomised comparison against intensity-modulated proton therapy. Delivery time and quality assurance are the practical barriers.

Generic schematic · not to scale · placeholder for the radiation front
Linac head + MLC · Target (PTV) · Gantry arc · Cone-beam CT guidance

How it works

Spot-scanned protons are delivered during continuous gantry rotation, with energy layers distributed across angles so each direction contributes only part of the dose.

Strengths
  • Better normal-tissue sparing than fixed-field proton therapy in planning studies
  • More robust to setup and range error
  • Runs on existing proton hardware
Limitations
  • No comparative clinical outcome data
  • Long delivery and QA times
  • Adds planning complexity for uncertain benefit

Latest papers

top
Latest papers · live from Europe PMC
Open in Europe PMC

Query for this technology: (TITLE:"Proton arc therapy" OR ABSTRACT:"Proton arc therapy") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about Proton arc therapy, not a curated reading list.

Connected

8top