Sarcoma (tissue type)
Cancer of the body's connective and supporting tissues: bone, muscle, fat, cartilage, blood vessels, fibrous tissue. Rare (about 1% of adult cancers) but relatively common in children.
Sarcomas come from mesenchymal cells rather than the epithelial lining cells that give rise to carcinomas, and there are more than seventy subtypes, many defined by a specific gene fusion (EWSR1-FLI1 in Ewing sarcoma, SS18-SSX in synovial sarcoma) or by a single driver (KIT in GIST). They are treated in specialist centres by surgery and radiotherapy, with chemotherapy for the more aggressive types; GIST was one of the first solid tumours transformed by a targeted drug (imatinib), and fusion-defined sarcomas are natural candidates for precision approaches. Because they are rare and diverse, sarcomas depend heavily on referral networks, registries and international trials.
Pages like this
not linked directly; found by shared links- TrialSSGXVIII/AIO (adjuvant imatinib in GIST)
Shares KIT, Imatinib, Sarcomas (soft tissue, bone, GIST).
- PersonCharles D. Blanke
Shares KIT, Imatinib, Sarcomas (soft tissue, bone, GIST).
- TermLeukaemia (tissue type)
Shares Carcinoma, Lymphoma (tissue type), Imatinib.
- TrialINVICTUS
Shares KIT, Sarcomas (soft tissue, bone, GIST).
- PersonJean-Yves Blay
Shares KIT, Imatinib, Sarcomas (soft tissue, bone, GIST).
- PersonOlivier Delattre
- PersonYoon-Koo Kang
Shares KIT, Imatinib, Sarcomas (soft tissue, bone, GIST).
- PairingctDNA KIT genotyping → TKI selection in GIST
Shares KIT, Sarcomas (soft tissue, bone, GIST).