Blinded independent central review (BICR)
Having outside radiologists who do not know the treatment assignment re-read every scan in a trial.
Regulators expect BICR for PFS and ORR endpoints in open-label trials to remove investigator bias; discordance between local and central reads is common and affects event counts. Delivered by imaging core labs.
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not linked directly; found by shared links- TermSingle-arm trial
Shares Blinding (double-blind, open-label, placebo-controlled), Objective response rate (ORR).
- IdeaRequire a randomised phase 2 before any phase 3
Shares Objective response rate (ORR), Progression-free survival (PFS).
- IdeaValidate real-world progression against central imaging review
Shares RECIST, Progression-free survival (PFS).
- IdeaMake clonal clearance, not tumour shrinkage, a trial endpoint
Shares RECIST, Progression-free survival (PFS).
- IdeaValidate real-world progression endpoints so pragmatic trials can use them
Shares RECIST, Progression-free survival (PFS).
- IdeaPublish the disagreement between trial doctors and independent reviewers for every trial
Shares RECIST, Progression-free survival (PFS).
- IdeaStructured, coded radiology reports for cancer response instead of free text
Shares RECIST, Progression-free survival (PFS).
- TermStable disease
Shares RECIST, Progression-free survival (PFS).