Imaging core labs and central review
Independent radiologists who re-read every scan in a trial the same way, so response rates mean the same thing across hospitals.
Blinded independent central review (BICR) applies RECIST, iRECIST, Lugano, or PCWG3 criteria consistently across sites and is expected by regulators for PFS and ORR endpoints. Vendors: Calyx (formerly Parexel Informatics), ICON Medical Imaging, Clario (Bioclinica + ERT), Median Technologies, WCG Imaging, and Radiology Partners' research arm. AI-assisted lesion tracking and quantitative imaging biomarkers are entering the workflow.
How it works
De-identified DICOM images uploaded to a central platform; two readers plus adjudicator score per protocol charter; discrepancy rates and read variability are tracked.
- Endpoint integrity
- Regulatory acceptance
- Cost and turnaround
- Discordance with local read (~30% of progression calls)
Latest papers
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