HRD & BRCA testing
Tests that reveal whether a tumour has a broken DNA repair system, which predicts response to PARP inhibitors and platinum.
Germline and somatic BRCA1/2 sequencing plus genomic-scar scores (myChoice CDx GIS, FoundationOne LOH) define HRD. Functional assays (RAD51 foci) and mutational signature 3 are emerging alternatives that may capture reversion.
How it works
Loss of heterozygosity, telomeric allelic imbalance, and large-scale transitions summed into a genomic instability score.
- Extends PARP-inhibitor benefit beyond BRCA carriers
- Scar is permanent even after resistance emerges
- Threshold debates
Latest papers
topQuery for this technology: (TITLE:"homologous recombination deficiency" OR ABSTRACT:"homologous recombination deficiency" OR TITLE:"HRD testing" OR ABSTRACT:"HRD testing" OR TITLE:"HRD score" OR ABSTRACT:"HRD score"). Results are unfiltered search hits about HRD & BRCA testing, not a curated reading list.
Pages like this
not linked directly; found by shared links- TrialPAOLA-1 / ENGOT-ov25
Shares ARCAGY-GINECO, Society of Gynecologic Oncology, Homologous recombination deficiency (HRD), PARP.
- ProductRucaparib
Shares Homologous recombination deficiency (HRD), Double-strand break repair: HR versus end joining, PARP, BRCA1 / BRCA2 (HRD).
- TechnologyPARP inhibitors
Shares A functional test for homologous recombination deficiency validated across laboratories, Mary-Claire King, ARCAGY-GINECO, Enabling characteristic: genome instability and mutation.
- ProductNiraparib
Shares ARCAGY-GINECO, DNA damage response & homologous recombination, Synthetic lethality: paired dependencies, Double-strand break repair: HR versus end joining.
- TargetATR
Shares Enabling characteristic: genome instability and mutation, DNA damage response & homologous recombination, Synthetic lethality: paired dependencies, Double-strand break repair: HR versus end joining.
- ProductTalazoparib
Shares DNA damage response & homologous recombination, Synthetic lethality: paired dependencies, Double-strand break repair: HR versus end joining, PARP.
- PathwayBase excision repair, PARP & alkylation damage
Shares Homologous recombination deficiency (HRD), DNA damage response & homologous recombination, Double-strand break repair: HR versus end joining, PARP.
- TargetWEE1
Shares DNA damage response & homologous recombination, Synthetic lethality: paired dependencies, Double-strand break repair: HR versus end joining, Ovarian cancer.