HIPEC / PIPAC (intraperitoneal chemotherapy)
Washing the abdominal cavity with heated chemotherapy during surgery to kill microscopic peritoneal deposits.
Survival benefit shown in ovarian cancer at interval debulking (OVHIPEC-1) and in pseudomyxoma; negative in colorectal (PRODIGE 7 for oxaliplatin HIPEC). PIPAC (pressurised aerosol) is a palliative laparoscopic alternative.
How it works
Direct peritoneal exposure at 41-43 °C enhances drug penetration.
- High local concentration
- Morbidity, centre expertise
- Mixed trial results
Latest papers
topQuery for this technology: (TITLE:"hyperthermic intraperitoneal chemotherapy" OR ABSTRACT:"hyperthermic intraperitoneal chemotherapy" OR TITLE:"HIPEC" OR ABSTRACT:"HIPEC" OR TITLE:"PIPAC" OR ABSTRACT:"PIPAC"). Results are unfiltered search hits about HIPEC / PIPAC (intraperitoneal chemotherapy), not a curated reading list.
Pages like this
not linked directly; found by shared links- TermPeritoneum and peritoneal metastases
Shares HIPEC (hyperthermic intraperitoneal chemotherapy), Debulking (cytoreductive surgery), Intraperitoneal (IP) chemotherapy, Mesothelioma.
- PersonAlessandro Gronchi
Shares Fondazione IRCCS Istituto Nazionale dei Tumori, European Society of Surgical Oncology.
- TechnologyRobotic & minimally invasive surgery
Shares First Affiliated Hospital of Sun Yat-sen University, Systemic versus local therapy, European Society of Surgical Oncology, Mandatory staged registries for new surgical techniques before wide adoption.
- TargetMesothelin
Shares Treat the body cavity, not the bloodstream, for surface spread, Mesothelioma, Ovarian cancer.
- InstitutionARCAGY-GINECO
Shares European Society of Gynaecological Oncology, UNICANCER, Ovarian cancer.
- ProductCAPOX (capecitabine, oxaliplatin)
Shares Appendiceal cancer and pseudomyxoma peritonei, Gastric & gastro-oesophageal junction cancer, Colorectal cancer.
- IdeaA video-based surgical quality registry linking assessed skill to cancer outcomes
Shares Mandatory staged registries for new surgical techniques before wide adoption, Gastric & gastro-oesophageal junction cancer, Colorectal cancer.
- ProductOxaliplatin
Shares Appendiceal cancer and pseudomyxoma peritonei, Gastric & gastro-oesophageal junction cancer, Colorectal cancer.