Oxaliplatin
The platinum drug that works in bowel cancer where cisplatin does not, the 'OX' in FOLFOX and CAPOX; its cost is nerve damage in hands and feet.
Approved EU 1996, US 2002 (second line, then adjuvant colon after MOSAIC 2004). FOLFOX/CAPOX backbone in colorectal, gastro-oesophageal (FLOT), pancreatic (FOLFIRINOX), biliary (second line), appendiceal and neuroendocrine (CAPTEM alternatives). IDEA (2018) showed 3 months of CAPOX suffices for low-risk stage III colon cancer, limiting neuropathy.
- Medicare
- Part B (clinician-administered)
Given by infusion or injection in a clinic or hospital outpatient department, so it is a Part B drug: Medicare pays 80% after the Part B deductible and the patient owes 20% coinsurance, uncapped in Original Medicare unless a Medigap policy applies. HCPCS J9263. Generic.
- Commercial insurance
- covered on label
Multi-source generic; covered under the medical benefit without prior authorisation in most plans, as part of standard regimens.
Sources: Medicare.gov: Chemotherapy · Medicare.gov: Prescription drugs (outpatient, Part B). Not medical or financial advice; verify with your plan.
- Appraised for
- Advanced colorectal cancer (FOLFOX-type regimens)
- Notes
- Also adjuvant stage III colon cancer (TA100, 2006). Generic; funded routinely.
- NHS England
- Routinely funded for the appraised indication (or via managed access)
Sources: NICE TA93 · SMC advice: oxaliplatin. Funding decisions are indication-specific and change monthly; verify with NICE and your treating team.
Approvals
| Region | Year | Indication |
|---|---|---|
| EU | 1996 | Metastatic colorectal cancer |
| US | 2002 | Metastatic colorectal cancer with 5-FU/LV |
| US | 2004 | Adjuvant stage III colon cancer |
Trials
topRecruiting now (live from ClinicalTrials.gov)
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Latest papers
topQuery for this drug: (TITLE:"Oxaliplatin" OR ABSTRACT:"Oxaliplatin" OR TITLE:"Eloxatin" OR ABSTRACT:"Eloxatin") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about Oxaliplatin, not a curated reading list.
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