FLOT regimen (perioperative chemotherapy for gastric cancer)
Four cycles of chemotherapy before and four after surgery for stomach and junction cancer, using fluorouracil, leucovorin, oxaliplatin and docetaxel. It replaced the older ECF recipe after the FLOT4 trial and is now the Western standard.
The MAGIC trial (2006) established perioperative ECF; FLOT4 (2019) showed FLOT improved median survival from 35 to 50 months and raised complete pathological responses. Adding PD-1 blockade (MATTERHORN durvalumab, KEYNOTE-585) improved event-free survival, and trastuzumab and zolbetuximab are being tested in HER2-positive and claudin 18.2-positive disease. FLOT is toxic (neutropenia, neuropathy, diarrhoea) and only about half of patients complete the postoperative half, so ctDNA-guided and response-adapted variants are under study. East Asian practice favours D2 surgery followed by adjuvant S-1 or CAPOX instead.
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not linked directly; found by shared links- TrialMATTERHORN
Shares FLOT (5-FU, leucovorin, oxaliplatin, docetaxel), Neoadjuvant / adjuvant / perioperative, Gastric & gastro-oesophageal junction cancer.
- TermPeripheral neuropathy (chemotherapy-induced)
Shares Oxaliplatin, FOLFOX, FOLFIRI, FOLFIRINOX and CAPOX, Docetaxel.
- TermOesophagectomy
Shares Gastro-oesophageal junction (GEJ), Oesophageal cancer, Gastric & gastro-oesophageal junction cancer.
- TrialCheckMate 577
Shares Neoadjuvant / adjuvant / perioperative, Oesophageal cancer, Gastric & gastro-oesophageal junction cancer.
- TermBarrett's oesophagus (Barrett's metaplasia)
Shares Gastro-oesophageal junction (GEJ), Oesophageal cancer.
- TermAlkylating agents and antimetabolites
Shares FOLFOX, FOLFIRI, FOLFIRINOX and CAPOX, Fluorouracil (5-FU).
- TrialCROSS
Shares Gastro-oesophageal junction (GEJ), Neoadjuvant / adjuvant / perioperative, Oesophageal cancer.
- TechnologyEndoscopic resection (EMR / ESD)
Shares Gastrectomy, Oesophageal cancer, Gastric & gastro-oesophageal junction cancer.