Gastro-oesophageal junction (GEJ)
Where the food pipe meets the stomach. Cancers here are classed by how far above or below the junction they centre (Siewert I-III), which decides whether they are treated like oesophageal or stomach cancer.
Adenocarcinoma of the GEJ has risen sharply in Western countries with obesity and reflux (via Barrett's oesophagus). Siewert type I (mainly oesophageal) is treated with chemoradiation (CROSS) and oesophagectomy; type III (mainly gastric) with perioperative FLOT and extended gastrectomy; type II either way. Drug trials for HER2, PD-L1 and claudin 18.2 usually enrol gastric and GEJ tumours together, so the label 'gastric or GEJ adenocarcinoma' is common on approvals.
Pages like this
not linked directly; found by shared links- TermEMR and ESD (endoscopic mucosal resection, endoscopic submucosal dissection)
Shares Barrett's oesophagus (Barrett's metaplasia), Oesophageal cancer, Gastric & gastro-oesophageal junction cancer.
- TechnologyEndoscopic resection (EMR / ESD)
Shares Barrett's oesophagus (Barrett's metaplasia), Gastrectomy, Oesophageal cancer, Gastric & gastro-oesophageal junction cancer.
- TrialCheckMate 577
Shares CROSS, Oesophageal cancer, Gastric & gastro-oesophageal junction cancer.
- TrialSANO
Shares Oesophagectomy, CROSS, Oesophageal cancer.
- ProductOxaliplatin
Shares FLOT regimen (perioperative chemotherapy for gastric cancer), Oesophageal cancer, Gastric & gastro-oesophageal junction cancer.
- TrialMATTERHORN
Shares FLOT (5-FU, leucovorin, oxaliplatin, docetaxel), Gastric & gastro-oesophageal junction cancer.
- ProductFluorouracil (5-FU)
Shares FLOT regimen (perioperative chemotherapy for gastric cancer), Oesophageal cancer, Gastric & gastro-oesophageal junction cancer.
- TermFeeding tube (gastrostomy, PEG, jejunostomy)
Shares Oesophagectomy, Oesophageal cancer.