CAPOX (capecitabine, oxaliplatin)
CAPOX combines oral capecitabine with oxaliplatin as a pill-based alternative to FOLFOX. Three months of it after surgery is enough for many stage III colon cancers.
IDEA collaboration (2018): 3 months of CAPOX is non-inferior to 6 for low-risk stage III (T1-3 N1) colon cancer, halving neuropathy. Standard perioperative and first-line option in gastric cancer (with nivolumab in CheckMate 649; with zolbetuximab in GLOW). Hand-foot syndrome from capecitabine replaces some 5-FU toxicity.
- Route
- Oral + intravenous
- Schedule
- Capecitabine 1,000 mg/m² twice daily days 1-14 + oxaliplatin 130 mg/m² day 1, every 21 days
- Dose modifications
- Reduce capecitabine for hand-foot syndrome or renal impairment
- Monitoring
- Blood counts, creatinine, neuropathy
| Adverse event |
|---|
| Hand-foot syndrome |
| Peripheral neuropathy |
| Diarrhoea |
Events listed without rates were not read from a primary source; see the label. Blank cells mean the figure was not sourced, not that it is zero.
Trials
topRecruiting now (live from ClinicalTrials.gov)
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Landmark trials in OnCo
Latest papers
topQuery for this drug: (TITLE:"CAPOX" OR ABSTRACT:"CAPOX" OR TITLE:"capecitabine, oxaliplatin" OR ABSTRACT:"capecitabine, oxaliplatin" OR TITLE:"XELOX" OR ABSTRACT:"XELOX") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about CAPOX (capecitabine, oxaliplatin), not a curated reading list.
Pages like this
not linked directly; found by shared links- ProductOxaliplatin
Shares Appendiceal cancer and pseudomyxoma peritonei, Platinum agents, Cytotoxic chemotherapy, Gastric & gastro-oesophageal junction cancer.
- ProductFLOT (5-FU, leucovorin, oxaliplatin, docetaxel)
Shares FOLFOX (5-FU, leucovorin, oxaliplatin), Platinum agents, Cytotoxic chemotherapy, Gastric & gastro-oesophageal junction cancer.
- ProductTrifluridine/tipiracil
Shares CIRCULATE-Japan (GALAXY / VEGA / ALTAIR), Cytotoxic chemotherapy, Gastric & gastro-oesophageal junction cancer, Colorectal cancer.
- IdeaBiomarker-directed first-line quadruplets in gastric cancer
Shares CheckMate 649, SPOTLIGHT & GLOW, Gastric & gastro-oesophageal junction cancer.
- PersonWon Ki Kang
Shares CheckMate 649, Gastric & gastro-oesophageal junction cancer.
- ProductMitomycin C
Shares Appendiceal cancer and pseudomyxoma peritonei, Cytotoxic chemotherapy, Gastric & gastro-oesophageal junction cancer.
- IdeaA prevention programme for chemotherapy nerve damage: SARM1 inhibitors, cooling and compression
Shares Platinum agents, Cytotoxic chemotherapy, Colorectal cancer.
- ProductFOLFIRI (5-FU, leucovorin, irinotecan)
Shares FOLFOX (5-FU, leucovorin, oxaliplatin), Cytotoxic chemotherapy, Colorectal cancer.