HIPEC (hyperthermic intraperitoneal chemotherapy)
After surgeons remove all visible tumour from the abdominal lining, the abdomen is bathed for 60-90 minutes in heated chemotherapy to kill the microscopic cells left behind.
Cytoreductive surgery plus HIPEC is standard for pseudomyxoma peritonei and appendiceal cancers and has randomised support in ovarian cancer (van Driel 2018, OVHIPEC-1) and gastric cancer prevention of peritoneal recurrence, but PRODIGE 7 showed no benefit of oxaliplatin HIPEC in colorectal peritoneal metastases, so its role there rests on complete cytoreduction alone. Heat (41-43°C) increases drug penetration to a few millimetres. PIPAC delivers aerosolised chemotherapy laparoscopically for unresectable peritoneal disease and is in trials.
Pages like this
not linked directly; found by shared links- TermPeritoneal metastasis
Shares HIPEC / PIPAC (intraperitoneal chemotherapy), Ovarian cancer, Gastric & gastro-oesophageal junction cancer, Colorectal cancer.
- InstitutionFirst Affiliated Hospital of Sun Yat-sen University
Shares HIPEC / PIPAC (intraperitoneal chemotherapy), Gastric & gastro-oesophageal junction cancer, Colorectal cancer.
- PairingHIPEC at interval cytoreductive surgery
Shares HIPEC / PIPAC (intraperitoneal chemotherapy), Ovarian cancer.
- TrialOVHIPEC-1
Shares HIPEC / PIPAC (intraperitoneal chemotherapy), Ovarian cancer.
- IdeaTreat the body cavity, not the bloodstream, for surface spread
Shares HIPEC / PIPAC (intraperitoneal chemotherapy), Ovarian cancer, Gastric & gastro-oesophageal junction cancer.
- IdeaPeritoneal-directed therapy for gastric cancer
Shares HIPEC / PIPAC (intraperitoneal chemotherapy), Gastric & gastro-oesophageal junction cancer.
- TargetEpCAM
Shares Ovarian cancer, Gastric & gastro-oesophageal junction cancer, Colorectal cancer.
- TermMalignant pleural effusion and ascites
Shares Peritoneum and peritoneal metastases, Ovarian cancer.