Paid independent statistical review for preclinical papers that inform trials
Clinical trials get expert statistical review; the laboratory studies that justify them usually do not. Paying statisticians to review these papers before they influence a trial would catch errors early.
Statistical errors in preclinical papers (pseudo-replication, inappropriate tests, no correction for multiple comparisons) are common and are rarely caught by biologist reviewers. Journals could not afford it; a funder-supported service that provides paid statistical review for preclinical papers cited in trial protocols or investigational new drug packages, with a published statistical report, would target the small fraction of papers that matter most for translation.
- Preclinical results do not reproduce · Fewer than half of landmark cancer biology findings reproduce when someone else tries.
- The valley of death between lab and product · Most academic discoveries die before anyone tests them in people because nobody funds the middle step.
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not linked directly; found by shared links- IdeaTop journals require an independent lab to reproduce key findings before publication
Shares Independent replication of the key experiment before first-in-human academic trials, Preclinical results do not reproduce.
- IdeaAn independent replication institute that re-tests key preclinical cancer findings before trials
Shares Preclinical results do not reproduce, The valley of death between lab and product.
- IdeaDeposit the raw blots, gels and microscopy images behind every figure
Shares Run automated statistics and image checks on every cancer manuscript before review, Preclinical results do not reproduce.
- IdeaMulti-laboratory preclinical trials as the standard for go/no-go decisions
Shares Independent replication of the key experiment before first-in-human academic trials, Preclinical results do not reproduce.
- IdeaMulti-centre randomised animal trials before committing to a human trial
Shares Preclinical results do not reproduce, The valley of death between lab and product.
- IdeaFunders set aside a fixed share of budget for independent replication
Shares Independent replication of the key experiment before first-in-human academic trials, Preclinical results do not reproduce.
- InstitutionEuropean Association for Cancer Research
Shares Preclinical results do not reproduce, The valley of death between lab and product.
- IdeaSelf-driving laboratories that run the cancer biology hypothesis loop autonomously
Shares Preclinical results do not reproduce, The valley of death between lab and product.