Stomach cancer serology screening for high-risk migrant communities in low-incidence countries
People who grew up in East Asia, Eastern Europe or Latin America keep a high stomach cancer risk after migrating. Cheap blood tests could select who needs an endoscopy.
Pepsinogen I/II ratio plus H. pylori serology (the ABC method) stratifies gastric cancer risk in Japan. Western countries do not screen because average incidence is low, but first-generation migrants from high-incidence regions carry two- to five-fold risk. Propose targeted serological screening with endoscopy for high-risk groups.
- Most lethal cancers are found late · Screening exists for only a few cancers. Pancreatic, ovarian, liver, oesophageal and most lung cancers are found when cure is unlikely.
- Trials do not represent the people who get cancer · Older, Black, Hispanic, Asian, rural, poor and multimorbid patients are under-represented, so results may not apply to them.
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- CompanyBeOne Medicines (formerly BeiGene)
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