A ten-dollar blood test for the five cancers that kill most people in poorer countries
Most cancer deaths are in low and middle income countries, where scans and endoscopies are scarce. A cheap methylation blood test tuned to liver, stomach, oesophageal, cervical and breast cancer could fill the gap.
Current MCEDs cost around $950 and target the US cancer mix. Propose a narrow-panel targeted-methylation assay on low-cost sequencing or PCR, optimised for cancers with high LMIC burden, validated in prospective LMIC cohorts, with a two-step protocol (positive leads to ultrasound or endoscopy).
- Most lethal cancers are found late · Screening exists for only a few cancers. Pancreatic, ovarian, liver, oesophageal and most lung cancers are found when cure is unlikely.
- Most of the world has almost no cancer care · Seven in ten cancer deaths happen in low- and middle-income countries, where radiotherapy, pathology, surgery and drugs are scarce.
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