Organ preservation as the default after complete response in oesophageal cancer
Oesophagectomy is one of the hardest operations in surgery. If chemoradiation (with or without immunotherapy) has made the tumour disappear, skip it and watch.
SANO showed non-inferior 2-year survival for active surveillance in clinical complete responders after CROSS. Adding PD-1 blockade to chemoradiation (KEYNOTE-975, SKYSCRAPER-07, ESCORT-CRT) may raise complete response rates and make surveillance viable for more patients; ctDNA and PET could sharpen response assessment.
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not linked directly; found by shared links- PairingCROSS chemoradiation → surgery → adjuvant nivolumab if residual disease
Shares Clinical complete response (cCR), SANO, CROSS, Oesophageal cancer.
- TermOesophagectomy
Shares SANO, CROSS, Oesophageal cancer.
- InstitutionZhejiang Cancer Hospital
Shares IMRT / IGRT (modern external beam), Oesophageal cancer, Immune checkpoint inhibitors.
- IdeaAdvanced-practice radiation therapists doing contouring and on-treatment reviews
Shares Surgery and radiotherapy cure most, get least, IMRT / IGRT (modern external beam).
- PersonYuko Kitagawa
Shares CROSS, Oesophageal cancer.
- TrialProtecT
Shares Active surveillance, Surgery and radiotherapy cure most, get least.
- IdeaSingle-fraction radiotherapy as the default for painful bone metastases
Shares Surgery and radiotherapy cure most, get least, IMRT / IGRT (modern external beam).
- InstitutionShandong Cancer Hospital and Institute
Shares IMRT / IGRT (modern external beam), Oesophageal cancer, Immune checkpoint inhibitors.