A dose-finding trial for exercise after cancer
CHALLENGE proved exercise works in colon cancer but not how much is needed. A trial comparing doses, as we would for a drug, would tell health systems what to fund.
Drugs get dose-finding; exercise got a single dose (about 10 MET-hours/week above baseline) chosen from cohort data. Cohorts suggest a dose-response with benefit continuing beyond 18 MET-hours/week, but also that the first few hours matter most. Health systems deciding what to reimburse need to know whether a cheaper, lower-dose or unsupervised programme retains most of the benefit.
- Survivorship and late effects are neglected · Tens of millions of people live after cancer with heart damage, infertility, second cancers and fear, and few services.
- Trial design, endpoints and cost · A phase 3 trial takes years and hundreds of millions of dollars, and often answers a question that has already moved on.
- Prevention we already have is not deployed · Around four in ten cancers are preventable with tools we already own: vaccines, tobacco control, weight, alcohol, sun and infection control.
Pages like this
not linked directly; found by shared links- Key paperCHALLENGE: a structured exercise programme after chemotherapy improves survival in colon cancer
Shares Pay for supervised exercise the way we pay for drugs, Structured exercise prescribed like a drug in all curative-intent cancer care, Exercise & lifestyle oncology, Survivorship and late effects are neglected.
- TechnologyTime-restricted eating in cancer prevention and survivorship
Shares Energy balance, Structured exercise programmes after curative treatment, Survivorship and late effects are neglected, Prevention we already have is not deployed.
- IdeaTrials of structured cognitive rehabilitation for cancer-related cognitive impairment
Shares Structured exercise prescribed like a drug in all curative-intent cancer care, Exercise & lifestyle oncology, Survivorship and late effects are neglected.
- IdeaA survivorship research endowment funded by a levy on curative therapy prices
Shares Structured exercise prescribed like a drug in all curative-intent cancer care, Exercise & lifestyle oncology, Survivorship and late effects are neglected, HR-positive / HER2-negative breast cancer.
- TechnologyExercise during chemotherapy and radiotherapy
Shares MET-hours per week, Exercise & lifestyle oncology, HR-positive / HER2-negative breast cancer, Colorectal cancer.
- IdeaFour weeks of training and nutrition before major cancer surgery, as standard
Shares Structured exercise prescribed like a drug in all curative-intent cancer care, Exercise & lifestyle oncology, Survivorship and late effects are neglected, Colorectal cancer.
- TrialBWEL (Breast Cancer Weight Loss, Alliance A011401)
Shares Energy balance, Exercise & lifestyle oncology, Survivorship and late effects are neglected, HR-positive / HER2-negative breast cancer.
- TechnologyDietitian-led weight-loss programmes in HR-positive breast cancer
Shares Energy balance, Structured exercise programmes after curative treatment, Exercise & lifestyle oncology, Survivorship and late effects are neglected.