An open supplement-drug interaction checker built into oncology prescribing
Most patients take supplements and rarely tell their oncologist. Ask routinely and check automatically for interactions with chemotherapy and targeted drugs.
Herbal and dietary supplement use is common in cancer patients and can alter drug metabolism (St John's wort, curcumin, green tea extract with certain kinase inhibitors) or interfere with treatment. Data are scattered across MSK's About Herbs, pharmacology references and case reports. The proposal is a curated open database of supplement-anticancer drug interactions with evidence grades, integrated into electronic prescribing so that documented supplement use triggers an alert, plus a standard intake question at every prescribing visit.
- Misinformation and unproven therapies · Patients are sold unproven treatments and frightened away from proven ones.
- Toxicity and quality of life are undervalued · Trials measure how long people live, not how they live. Side-effects are under-reported and under-treated.
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