Loncastuximab tesirine
Loncastuximab tesirine (Zynlonta) is a CD19 ADC with a DNA-crosslinking payload for relapsed large B-cell lymphoma.
Approved 2021 for relapsed/refractory DLBCL after ≥2 lines (LOTIS-2, ORR 48%). PBD payloads are extremely potent but carry oedema, photosensitivity, and effusion toxicity, limiting the class in solid tumours.
1.Antibody binds CD19 on the tumour cell surface
- Route
- IV infusion
- Schedule
- 0.15 mg/kg every 3 weeks for 2 cycles, then 0.075 mg/kg every 3 weeks; dexamethasone premedication
- Dose modifications
- Hold for grade ≥3 oedema/effusion or cytopenias
- Monitoring
- Weight and fluid status, blood counts, LFTs, photosensitivity precautions
Source: www.fda.gov/drugs/resources-information-approved-drugs/oncology-cancer-hematologic-malignancies-approval-notifications. Doses are for orientation; the current label governs.
- Medicare
- Part B (clinician-administered)
Given by infusion or injection in a clinic or hospital outpatient department, so it is a Part B drug: Medicare pays 80% after the Part B deductible and the patient owes 20% coinsurance, uncapped in Original Medicare unless a Medigap policy applies.
- Commercial insurance
- covered with prior authorisation
Covered under the medical benefit with prior authorisation confirming diagnosis, biomarker status and line of therapy; site-of-care policies may steer infusions away from hospital outpatient departments.
- Assistance programmes
- PAN Foundation — Disease-specific co-pay and premium funds; open and closed funds change monthly.
- HealthWell Foundation
- CancerCare Co-Payment Assistance Foundation
- Patient Advocate Foundation Co-Pay Relief
- Leukemia & Lymphoma Society financial support
20% Part B coinsurance on a high-cost infusion adds up quickly: Medigap Plan G or N, Medicare Advantage maximum out-of-pocket, Medicaid dual eligibility, or a charity fund are the usual buffers.
Sources: Medicare.gov: Chemotherapy · Medicare.gov: Prescription drugs (outpatient, Part B). Not medical or financial advice; verify with your plan.
- Notes
- MHRA-licensed 2023 for relapsed or refractory DLBCL; NICE position not yet researched.
Sources: NICE search: loncastuximab tesirine. Funding decisions are indication-specific and change monthly; verify with NICE and your treating team.
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- 23 Apr 2021ApprovalUS
Accelerated approval, relapsed/refractory DLBCL after ≥2 lines (LOTIS-2) source
- Dec 2022ApprovalEU
Conditional marketing authorisation source
Approvals
| Region | Year | Indication |
|---|---|---|
| US | 2021 | Relapsed/refractory DLBCL after ≥2 systemic therapies |
| Adverse event |
|---|
| Thrombocytopenia |
| Increased GGT |
| Neutropenia |
| Anaemia |
| Fatigue |
| Oedema and effusions |
| Photosensitivity/rash |
Events listed without rates were not read from a primary source; see the label. Blank cells mean the figure was not sourced, not that it is zero.
| Country | Reimbursement | List price | Assistance |
|---|---|---|---|
| United States | Medicare Part B (physician-administered); commercial plans per formulary | not disclosed | — |
List prices are manufacturer or Medicare figures where publicly disclosed; net prices after rebates are usually lower. Reimbursement changes; check the payer.
Trials
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Latest papers
topQuery for this drug: (TITLE:"Loncastuximab tesirine" OR ABSTRACT:"Loncastuximab tesirine" OR TITLE:"Zynlonta" OR ABSTRACT:"Zynlonta") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about Loncastuximab tesirine, not a curated reading list.
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