termsTerm
Val-Ala dipeptide
aka valine-alanine linker
The Val-Ala dipeptide linker is easier to manufacture and less prone to aggregation than valine-citrulline, and is used with PBD payloads.
Valine-alanine is cleaved by cathepsin B like valine-citrulline but is more hydrophilic, which matters when the payload is very hydrophobic, as PBD dimers are. Used in loncastuximab tesirine.
Category
ADC chemistry
Pages like this
not linked directly; found by shared links- TermDNA crosslinker payloads (PBD dimers)
Shares PBD dimer (SG3199 / tesirine), Loncastuximab tesirine, Antibody-drug conjugate (ADC).
- TermSMCC (thioether, non-cleavable)
- TermSulfo-SPDB (disulfide)
- TermMaleimidocaproyl (mc), non-cleavable
- TermAcid-labile hydrazone (AcBut)
- TermCL2A
- TermHydrophilic next-generation linkers (TMALIN, Dolaflexin, sulfonyl-pyrimidine, PEG-containing)
- TermTetrapeptide GGFG (maleimide-GGFG-aminomethyl)