Linker (ADC)
The linker is the chemical tether between antibody and payload. It must hold in the blood and let go inside the tumour.
Cleavable linkers (protease-sensitive peptides like Val-Cit or GGFG, acid-labile hydrazones, glutathione-sensitive disulfides) release free payload; non-cleavable linkers (SMCC in T-DM1) release payload still attached to an amino acid, which cannot cross membranes. Linker hydrophilicity permits high DAR without aggregation.
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not linked directly; found by shared links- TermDrug-to-antibody ratio (DAR)
Shares Hydrophilic next-generation linkers (TMALIN, Dolaflexin, sulfonyl-pyrimidine, PEG-containing), Site-specific conjugation & linker chemistry, Antibody-drug conjugate (ADC).
- CompanyAraris Biotech (Taiho)
Shares Platform designation for ADC linker-payloads so manufacturing data carry across, Site-specific conjugation & linker chemistry, Antibody-drug conjugate (ADC).
- CompanySynaffix (Lonza)
Shares Platform designation for ADC linker-payloads so manufacturing data carry across, Site-specific conjugation & linker chemistry, Antibody-drug conjugate (ADC).
- TermCalicheamicin
Shares Acid-labile hydrazone (AcBut), Antibody-drug conjugate (ADC).
- TermPBD dimer (SG3199 / tesirine)
- TermMMAF
Shares Maleimidocaproyl (mc), non-cleavable, Antibody-drug conjugate (ADC).
- TermBystander effect (ADC)
Shares CL2A, mc-Val-Cit-PABC, Antibody-drug conjugate (ADC).
- TermDM1
Shares SMCC (thioether, non-cleavable), Antibody-drug conjugate (ADC).