Giredestrant
Giredestrant is Roche's oral SERD: it failed to beat an aromatase inhibitor in first-line metastatic disease but succeeded after surgery and after CDK4/6 failure.
evERA (with everolimus after CDK4/6): PFS HR 0.56, HR 0.38 in ESR1-mutant; NDA accepted February 2026. lidERA (adjuvant): ~30% fewer invasive recurrences than standard endocrine therapy (SABCS 2025). persevERA (first-line with palbociclib): missed its primary endpoint (March 2026). Together these define where oral SERDs add value: resistance and adjuvant settings rather than upfront in unselected metastatic disease.
- Route
- Oral
- Schedule
- 30 mg once daily (trial dose)
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Trials
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Landmark trials in OnCo
Latest papers
topQuery for this drug: (TITLE:"Giredestrant" OR ABSTRACT:"Giredestrant" OR TITLE:"GDC-9545" OR ABSTRACT:"GDC-9545" OR TITLE:"RG6171" OR ABSTRACT:"RG6171") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about Giredestrant, not a curated reading list.
Pages like this
not linked directly; found by shared links- ProductExemestane
Shares evERA, Estrogen receptor (ERα), Endocrine therapy (SERMs, AIs, SERDs), HR-positive / HER2-negative breast cancer.
- ProductCamizestrant
Shares Oral SERD, Intercepting late recurrence with ctDNA surveillance and oral SERDs, Estrogen receptor (ERα), Endocrine therapy (SERMs, AIs, SERDs).
- ProductImlunestrant
Shares Oral SERD, Estrogen receptor (ERα), Endocrine therapy (SERMs, AIs, SERDs), HR-positive / HER2-negative breast cancer.
- TrialEMBER-3
Shares Oral SERD, Estrogen receptor (ERα), HR-positive / HER2-negative breast cancer.
- InstitutionBarbara Ann Karmanos Cancer Institute
Shares Estrogen receptor (ERα), Endocrine therapy (SERMs, AIs, SERDs), HR-positive / HER2-negative breast cancer.
- ProductElacestrant
Shares Oral SERD, Estrogen receptor (ERα), Endocrine therapy (SERMs, AIs, SERDs), HR-positive / HER2-negative breast cancer.
- ProductGoserelin / leuprolide (ovarian function suppression)
Shares Estrogen receptor (ERα), Endocrine therapy (SERMs, AIs, SERDs), HR-positive / HER2-negative breast cancer.
- ProductFulvestrant
Shares Oral SERD, Estrogen receptor (ERα), Endocrine therapy (SERMs, AIs, SERDs), HR-positive / HER2-negative breast cancer.