BioNTech
From COVID vaccine to a broad oncology pipeline: personalised vaccines, ADCs from China, and a PD-L1×VEGF bispecific sold to BMS for $11B.
Autogene cevumeran (with Genentech), BNT323/trastuzumab pamirtecan (DualityBio), pumitamig (BNT327, PD-L1×VEGF, BMS partnership), BNT113 (HPV16), CAR-T BNT211 (CLDN6).
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not linked directly; found by shared links- CompanyModerna
Shares Self-amplifying and circular RNA therapeutics, Vaccines aimed only at mutations shared by every tumour cell, Personalised cancer vaccines at commodity cost through fully automated manufacturing, Personalised vaccines given only when the blood test turns positive.
- PairingPersonalised neoantigen vaccine + PD-1 blockade
Shares Autogene cevumeran, Rojas 2023: a personalised mRNA vaccine trained T cells against each patient's pancreatic cancer, and those who responded stayed cancer-free longer, Personalised neoantigen (mRNA) vaccines, Pancreatic ductal adenocarcinoma.
- TrialINTerpath-001 (V940-001)
Shares Vaccines aimed only at mutations shared by every tumour cell, Rojas 2023: a personalised mRNA vaccine trained T cells against each patient's pancreatic cancer, and those who responded stayed cancer-free longer, Personalised neoantigen (mRNA) vaccines, Cold tumours and the immunosuppressive microenvironment.
- ProductIntismeran autogene
Shares Personalised cancer vaccines at commodity cost through fully automated manufacturing, Personalised vaccines given only when the blood test turns positive, Rojas 2023: a personalised mRNA vaccine trained T cells against each patient's pancreatic cancer, and those who responded stayed cancer-free longer, Personalised neoantigen (mRNA) vaccines.
- TermNeoantigen
Shares Vaccines aimed only at mutations shared by every tumour cell, Personalised cancer vaccines at commodity cost through fully automated manufacturing, University Cancer Center Mainz (UCT Mainz) / Universitätsmedizin Mainz, Personalised vaccines given only when the blood test turns positive.
- IdeaWhat makes a neoantigen actually immunogenic?
Shares Autogene cevumeran, Personalised neoantigen (mRNA) vaccines.
- IdeaOff-the-shelf KRAS vaccines after pancreatic cancer surgery
Shares Autogene cevumeran, Pancreatic ductal adenocarcinoma.
- IdeaLosartan to loosen the stroma of pancreatic cancer before chemotherapy: a phase 3
Shares Cold tumours and the immunosuppressive microenvironment, Pancreatic ductal adenocarcinoma.