LACC (Laparoscopic Approach to Cervical Cancer)
Keyhole surgery, assumed equivalent, turned out to be worse: more recurrences and more deaths than open surgery, reversing practice overnight.
4.5-year disease-free survival 86.0% vs 96.5% and OS HR for death 6.00 with minimally invasive surgery (NEJM 2018); the final analysis (2024) confirmed inferiority. Guidelines now recommend open radical hysterectomy; tumour spillage from uterine manipulators and CO2 is the leading hypothesis. Trials of protective manoeuvres (RACC, ROCC) are ongoing.
- 86 vs 96.5 out of 100 alive without the cancer coming back at 4.5 years with Minimally invasive compared with Open surgery; 10.5 fewer per 100.
- On this measure the first group did worse, not better.
- Put another way, the treated group had about 274 percent higher chance of the event at any given time (hazard ratio 3.74, likely range 1.63 to 8.58).
- This is a surrogate endpoint: it measures the cancer being controlled or absent on scans and tests, which often, but not always, translates into living longer.
- These results apply to the people the trial enrolled: Early-stage cervical cancer (IA1 with LVSI to IB1): minimally invasive vs open radical hysterectomy. People in a different situation may not see the same effect.
Numbers are from the trial as recorded here; see the source links in the table below. This is orientation, not medical advice: ask your team how closely the trial population matches you.
631 participants enrolled.
| Endpoint | Arm | n | Value | HR (95% CI) | p | Source |
|---|---|---|---|---|---|---|
| Disease-free survival at 4.5 yearsprimary | Minimally invasive | 319 | 86% | 3.74 (1.63–8.58) | — | link |
| Open surgery | 312 | 96.5% |
Pages like this
not linked directly; found by shared links- TrialOUTBACK / ANZGOG 0902 / GOG-0274
Shares Cervical cancer and the tag failure.
- PersonPeter W. T. Pisters
Shares MD Anderson Cancer Center, Robotic & minimally invasive surgery.
- IdeaModernised cobalt-60 machines as a deliberate bridge where linacs cannot be kept running
Shares Surgery and radiotherapy cure most, get least, Cervical cancer.
- IdeaLow-cost cobalt-60 brachytherapy for cervical cancer in every regional centre
Shares Surgery and radiotherapy cure most, get least, Cervical cancer.
- IdeaA consented commons of surgical video linked to pathology and outcomes
Shares Robotic & minimally invasive surgery, Surgery and radiotherapy cure most, get least.
- InstitutionEuropean Society of Gynaecological Oncology
Shares Society of Gynecologic Oncology, Robotic & minimally invasive surgery, Cervical cancer.
- InstitutionRajiv Gandhi Cancer Institute and Research Centre
Shares Robotic & minimally invasive surgery, Cervical cancer.
- TrialKEYNOTE-A18 / ENGOT-cx11 / GOG-3047