Stereotactic body radiotherapy (SBRT / SABR)
A few (1-5) very large, pinpoint-accurate radiation doses that destroy a tumour outside the brain almost like surgery, in patients who cannot or prefer not to have an operation.
Made possible by image guidance and motion management, SBRT gives local control above 90% for early lung cancer (the standard for inoperable stage I), treats liver, pancreatic, kidney, spine and prostate tumours (5-fraction PACE-B), and is the backbone of oligometastatic treatment, where SABR-COMET showed a survival gain. Ultra-high doses per fraction exploit different radiobiology (vascular damage, immune priming), hence the abscopal-effect trials with checkpoint inhibitors. Toxicity is mostly to whatever lies within a centimetre of the target.
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not linked directly; found by shared links- TermBrachytherapy (internal radiotherapy)
Shares Re-irradiation, Gray unit (Gy), IMRT / IGRT / VMAT (modern external beam radiotherapy), Hypofractionation (fewer, larger radiotherapy doses).
- TermOligoprogression
Shares Oligometastatic disease, SBRT / SABR (stereotactic radiotherapy).
- IdeaBiopsy the one lesion that is growing while the others shrink
Shares Oligometastatic disease, SBRT / SABR (stereotactic radiotherapy).
- TechnologyPalliative radiotherapy
Shares Bone metastases and skeletal-related events, SBRT / SABR (stereotactic radiotherapy).
- IdeaPSMA-PET-guided metastasis-directed therapy as a curative strategy in oligorecurrent prostate cancer
Shares Oligometastatic disease, SBRT / SABR (stereotactic radiotherapy).
- InstitutionHarold C. Simmons Comprehensive Cancer Center, UT Southwestern
Shares Oligometastatic disease, SBRT / SABR (stereotactic radiotherapy).
- IdeaA test to tell true oligometastatic disease from hidden widespread spread
Shares Oligometastatic disease, SBRT / SABR (stereotactic radiotherapy).
- InstitutionIRCCS Humanitas Research Hospital
Shares Oligometastatic disease, SBRT / SABR (stereotactic radiotherapy).