Bone metastases and skeletal-related events
Cancer spread to the bones, most common in prostate, breast, lung, kidney and thyroid cancer and myeloma. It causes pain, fractures and high calcium, and the complications are counted in trials as 'skeletal-related events'.
Skeletal-related events (fracture, need for radiotherapy or surgery to bone, spinal cord compression, hypercalcaemia) are reduced 30-40% by bone-modifying agents (zoledronic acid, denosumab). Single-fraction 8 Gy radiotherapy relieves pain as well as longer courses; SBRT gives more durable relief for spine metastases. Bone-seeking radiopharmaceuticals (radium-223, strontium-89) treat bone-predominant prostate cancer, and bone-only disease has a better prognosis than visceral spread in breast cancer. Spinal cord compression is an emergency needing steroids and urgent radiotherapy or surgery.
Pages like this
not linked directly; found by shared links- TechnologyCancer pain management
Shares Bone-modifying agents (bisphosphonates, denosumab), Palliative radiotherapy, Radium-223 dichloride.
- TermIMRT / IGRT / VMAT (modern external beam radiotherapy)
Shares Stereotactic body radiotherapy (SBRT / SABR), Hypofractionation (fewer, larger radiotherapy doses).
- TrialALSYMPCA
Shares Radium-223 dichloride, Prostate cancer.
- TermGray unit (Gy)
Shares Stereotactic body radiotherapy (SBRT / SABR), Hypofractionation (fewer, larger radiotherapy doses).
- TermBrachytherapy (internal radiotherapy)
Shares Hypofractionation (fewer, larger radiotherapy doses), Prostate cancer.
- TermLumpectomy (breast-conserving surgery)
Shares Hypofractionation (fewer, larger radiotherapy doses), HR-positive / HER2-negative breast cancer.
- IdeaKidney and liver impairment dosing studies completed before approval, not years after
Shares Renal cell carcinoma, Multiple myeloma.
- IdeaFix the neutrophil count rule that excludes many people of African ancestry
Shares Multiple myeloma, Prostate cancer.