Oligoprogression
When only one or two spots grow on an otherwise working targeted therapy; treat the spots and keep the pill.
Local ablative therapy (SBRT, surgery) to the progressing lesions with continuation of the TKI extends time on effective systemic therapy in ALK- and EGFR-driven NSCLC. Distinct from oligometastatic disease at diagnosis.
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not linked directly; found by shared links- IdeaPSMA-PET-guided metastasis-directed therapy as a curative strategy in oligorecurrent prostate cancer
Shares A test to tell true oligometastatic disease from hidden widespread spread, Oligometastatic disease, Metastasis is understood least and studied last, SBRT / SABR (stereotactic radiotherapy).
- IdeaBiopsy the one lesion that is growing while the others shrink
Shares Oligometastatic disease, Tumour heterogeneity and clonal evolution, SBRT / SABR (stereotactic radiotherapy), Non-small-cell lung cancer.
- IdeaBuild laboratory models of the organs cancer spreads to
Shares Oligometastatic disease, Metastasis is understood least and studied last.
- IdeaA regulatory endpoint for drugs that block spread, not tumours
Shares Oligometastatic disease, Metastasis is understood least and studied last.
- IdeaReprogramme the liver's own immune cells to refuse metastases
Shares Oligometastatic disease, Metastasis is understood least and studied last.
- InstitutionHarold C. Simmons Comprehensive Cancer Center, UT Southwestern
Shares Oligometastatic disease, SBRT / SABR (stereotactic radiotherapy), Non-small-cell lung cancer.
- IdeaMatch each blood-detected clone to the lesion it comes from on the scan
Shares Tumour heterogeneity and clonal evolution, Metastasis is understood least and studied last.
- InstitutionIRCCS Humanitas Research Hospital
Shares Oligometastatic disease, SBRT / SABR (stereotactic radiotherapy), Non-small-cell lung cancer.