Muscle-invasive (MIBC) vs non-muscle-invasive (NMIBC) bladder cancer
Bladder cancer is split by whether it has grown into the bladder's muscle wall. Non-muscle-invasive tumours (75%) are scraped out and treated with drugs put into the bladder; muscle-invasive tumours (25%) need the bladder removed or intensive chemoradiation.
NMIBC (Ta, T1, carcinoma in situ) is risk-stratified (EAU/AUA groups) to TURBT alone, single-dose intravesical chemotherapy, or induction and maintenance BCG, with 'BCG-unresponsive' disease (a regulatory definition) treated by cystectomy or the newer intravesical and systemic options (pembrolizumab, nadofaragene, TAR-200, cretostimogene). MIBC (T2-T4) requires neoadjuvant cisplatin-based chemotherapy (or durvalumab-chemotherapy, NIAGARA) and radical cystectomy, or trimodality bladder preservation; adjuvant nivolumab or ctDNA-guided atezolizumab (IMvigor011) follows high-risk surgery. Progression from NMIBC to MIBC is the event surveillance aims to prevent.
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not linked directly; found by shared links- TermStoma (colostomy, ileostomy, urostomy)
Shares Radical cystectomy, Organ preservation (watch-and-wait, bladder-sparing, larynx preservation), Bladder & urothelial cancer.
- TermCarcinoma in situ (CIS)
Shares Intravesical therapy (BCG and bladder instillations), Bladder & urothelial cancer.
- TermNon-muscle-invasive vs muscle-invasive bladder cancer (NMIBC / MIBC)
Shares NIAGARA, Bladder & urothelial cancer.
- IdeaA national residual-disease weather service: serial blood tests for every curatively treated patient, pooled
Shares IMvigor011, Bladder & urothelial cancer.
- PairingctDNA MRD → adjuvant therapy decision
Shares IMvigor011, Bladder & urothelial cancer.
- Key paperIMvigor011: using a blood test for leftover cancer to decide who gets immunotherapy after bladder surgery
Shares IMvigor011, Bladder & urothelial cancer.
- TermChemoradiation (chemoradiotherapy, CRT)
Shares Organ preservation (watch-and-wait, bladder-sparing, larynx preservation), Bladder & urothelial cancer.
- ProductSignatera
Shares IMvigor011, Bladder & urothelial cancer.