Duration of response
How long a tumour stays shrunk once it has responded to a drug. A response that lasts two years is worth far more than one that lasts two months, so this is reported alongside response rate.
Measured from the first documented response to progression or death, and usually reported as a median plus the proportion of responders still responding at 6, 12 or 24 months. Immunotherapy's signature is not a high response rate but a long duration of response, with responses lasting years in a subset; conversely, many chemotherapy responses are brisk but short. Regulators weigh response rate and durability together when granting accelerated approval on single-arm data, and the durable-response tail is what turns survival curves into a plateau.
Pages like this
not linked directly; found by shared links- TermStable disease
Shares Complete response, Partial response, Progression-free survival (PFS).
- TermSurrogate endpoint
Shares Partial response, Objective response rate (ORR), Accelerated approval, Progression-free survival (PFS).
- TermDuration of response (DoR) and disease control rate (DCR)
Shares Objective response rate (ORR), Accelerated approval, Progression-free survival (PFS).
- TermRemission
Shares Complete response, Partial response.
- IdeaRequire a randomised phase 2 before any phase 3
Shares Objective response rate (ORR), Progression-free survival (PFS).
- TermProgression
Shares Complete response, Partial response, Progression-free survival (PFS).
- IdeaProvisional prices for surrogate-endpoint approvals, reset when survival data arrive
Shares Accelerated approval, Progression-free survival (PFS).
- IdeaAn independent programme that validates surrogate endpoints, setting by setting
Shares Objective response rate (ORR), Accelerated approval, Progression-free survival (PFS).