Complete response
All detectable signs of the tumour have vanished on scans and examination after treatment. The best result a trial can record for an individual patient, though microscopic disease may remain.
Under RECIST, complete response means every target lesion has disappeared and any lymph nodes have shrunk below 10 mm; it must be confirmed on a repeat scan. Complete responses are common in lymphomas and germ-cell tumours and were historically rare in solid tumours, so their appearance with immunotherapy and cell therapy (around 20% in metastatic melanoma with ipilimumab plus nivolumab, most of them lasting) was a genuine change. Pathologic complete response is the surgical equivalent: no cancer cells found in the removed tissue after pre-operative treatment.
Pages like this
not linked directly; found by shared links- TermSurrogate endpoint
Shares Partial response, Pathologic complete response (pCR), Objective response rate (ORR).
- TermRecurrence and relapse
Shares Remission, Progression.
- TermMaintenance therapy
Shares Remission, Progression.
- TermComplete response (CR) and partial response (PR)
Shares RECIST, Pathologic complete response (pCR), Objective response rate (ORR).
- TermBlinded independent central review (BICR)
Shares RECIST, Objective response rate (ORR).
- IdeaAn independent programme that validates surrogate endpoints, setting by setting
Shares Pathologic complete response (pCR), Objective response rate (ORR).
- Key paperPrasad: most surrogate endpoints in cancer trials correlate poorly with survival
Shares RECIST, Objective response rate (ORR).
- TermEndpoint
Shares Pathologic complete response (pCR), Objective response rate (ORR).