Spatial biology instruments
Spatial biology instruments are machines that map which genes and proteins are active in each part of a tumour slice.
10x Genomics (Visium HD, Xenium), Bruker Spatial Biology (formerly NanoString GeoMx and CosMx), Vizgen (MERSCOPE), Akoya Biosciences (PhenoCycler) and Lunaphore/Bio-Techne (COMET) sell instruments and reagents for spatial transcriptomics and multiplexed protein imaging. Patent litigation reshaped the market (NanoString bankruptcy and acquisition by Bruker, 2024). Clinical use is nascent; the research impact on tumour microenvironment biology is large.
How it works
In situ hybridisation with barcoded probes imaged over many cycles, or capture arrays that record position, followed by sequencing.
- Preserves tissue architecture
- Hundreds to thousands of genes per section
- Cost per section
- Analysis complexity
- Not yet reimbursed clinically
Latest papers
topQuery for this technology: (TITLE:"Spatial biology instruments" OR ABSTRACT:"Spatial biology instruments") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about Spatial biology instruments, not a curated reading list.
Pages like this
not linked directly; found by shared links- TechnologyProteomics instruments and affinity platforms
Shares Bruker (Bruker Spatial Biology) and the tag supporting.
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