RFdiffusion / RFdiffusion2 and ProteinMPNN (Baker Lab)
The tools that design entirely new proteins to bind a chosen target, now used for cancer binders and antibodies.
RFdiffusion (Nature 2023) generates protein backbones; ProteinMPNN designs sequences; RFdiffusion2 (2025) designs enzymes; RFantibody extends to antibodies. Basis of Xaira and many binder programmes.
How it works
Denoising diffusion over protein backbones conditioned on a target.
- Validated de novo binders
- Developability and immunogenicity still empirical
Latest papers
topQuery for this technology: (TITLE:"RFdiffusion / RFdiffusion2 and ProteinMPNN" OR ABSTRACT:"RFdiffusion / RFdiffusion2 and ProteinMPNN" OR TITLE:"Baker Lab" OR ABSTRACT:"Baker Lab") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about RFdiffusion / RFdiffusion2 and ProteinMPNN (Baker Lab), not a curated reading list.
Pages like this
not linked directly; found by shared links- TechnologyESM3 (EvolutionaryScale)
Shares AI-driven drug & target discovery and the tags foundation-model, protein-design.
- TechnologyChai-1 / Chai-2
Shares AI-driven drug & target discovery and the tags foundation-model, protein-design.
- TechnologyPhenom-2 and Recursion OS
Shares AI-driven drug & target discovery and the tag foundation-model.
- TechnologyBoltz-1 / Boltz-2 (MIT, open)
Shares AI-driven drug & target discovery and the tag foundation-model.
- TechnologyAlphaFold 3
Shares AI-driven drug & target discovery and the tag foundation-model.