Chai-1 / Chai-2
Structure and antibody-design models from Chai Discovery, with Chai-2 reporting high zero-shot antibody hit rates.
Chai-1 (2024) open weights; Chai-2 (2025) reported ~16% zero-shot binder hit rates across dozens of targets in wet-lab tests.
How it works
Diffusion structure prediction; generative design conditioned on target epitope.
- De novo antibody design
- Independent replication pending
Latest papers
topQuery for this technology: (TITLE:"Chai-1 / Chai-2" OR ABSTRACT:"Chai-1 / Chai-2") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about Chai-1 / Chai-2, not a curated reading list.
Pages like this
not linked directly; found by shared links- TechnologyESM3 (EvolutionaryScale)
Shares AI-driven drug & target discovery and the tags foundation-model, protein-design.
- TechnologyRFdiffusion / RFdiffusion2 and ProteinMPNN (Baker Lab)
Shares AI-driven drug & target discovery and the tags foundation-model, protein-design.
- TechnologyPhenom-2 and Recursion OS
Shares AI-driven drug & target discovery and the tag foundation-model.
- TechnologyBoltz-1 / Boltz-2 (MIT, open)
Shares AI-driven drug & target discovery and the tag foundation-model.
- TechnologyAlphaFold 3
Shares AI-driven drug & target discovery and the tag foundation-model.