ESM3 (EvolutionaryScale)
ESM3 is a generative protein model that designed a working fluorescent protein far from any natural sequence.
Science 2025: 98B parameters over sequence, structure and function tokens; esmGFP demonstrated generation of novel functional proteins.
Generic schematic · not to scale · placeholder for the drug discovery front
Guide RNA library · Knockout → dependency
How it works
ESM3 is a masked multimodal transformer over protein tokens.
Strengths
- Joint sequence-structure-function
Limitations
- Largest weights closed
Since
2024
Latest papers
topLatest papers · live from Europe PMC
Query for this technology: (TITLE:"ESM3" OR ABSTRACT:"ESM3" OR TITLE:"EvolutionaryScale" OR ABSTRACT:"EvolutionaryScale") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about ESM3 (EvolutionaryScale), not a curated reading list.