Closed automated cell-therapy manufacturing
Sealed, robot-run machines that turn a patient's blood cells into a CAR-T product with far fewer hands, clean rooms, and mistakes.
Functionally closed, GMP-in-a-box platforms (Miltenyi CliniMACS Prodigy, Lonza Cocoon, Cellares Cell Shuttle, Cytiva Sefia) integrate cell selection, activation, transduction, expansion, and harvest in single-use cassettes. They cut labour and clean-room grade requirements, shorten vein-to-vein time, and are the prerequisite for point-of-care and decentralised manufacturing. Throughput per unit and comparability across sites remain the constraints.
How it works
Single-use fluid paths with integrated centrifugation, magnetic selection, incubation, and sensors; process recipes run automatically and log every step for batch release.
- Fewer open manipulations and contamination events
- Lower clean-room grade needed
- Reproducible, software-logged processes
- Capital cost per unit
- Process comparability when moving between platforms
- Still 7-14 days of culture for most products
Latest papers
topQuery for this technology: (TITLE:"Closed automated cell-therapy manufacturing" OR ABSTRACT:"Closed automated cell-therapy manufacturing") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about Closed automated cell-therapy manufacturing, not a curated reading list.
Pages like this
not linked directly; found by shared links- TechnologyViral vector manufacturing (lentiviral, retroviral, AAV)
Shares Cytiva (Danaher), Lonza, CAR-T cell therapy and the tag supporting.
- TechnologyApheresis and starting-material collection
Shares Terumo Blood and Cell Technologies, CAR-T cell therapy and the tag supporting.
- TechnologyCell-therapy orchestration and chain-of-identity software
Shares Vein-to-vein time and manufacturing slots, CAR-T cell therapy and the tag supporting.
- CompanyGalapagos
Shares Point-of-care and decentralised cell manufacturing and the tag supporting.
- CompanyCharles River Laboratories
Shares Cell-therapy release and potency testing and the tag supporting.
- CompanyBD (Becton, Dickinson and Company)
Shares Cell-therapy release and potency testing and the tag supporting.
- TechnologyPayload-linker synthesis (high-potency API)
Shares Lonza and the tag supporting.
- TechnologyAntibody manufacturing (CHO bioprocessing)
Shares Lonza and the tag supporting.