Boron neutron capture therapy
In boron neutron capture therapy a boron drug accumulates in tumour cells, then a neutron beam makes only those cells explode from inside.
Approved in Japan (2020) for recurrent head and neck cancer using accelerator-based neutron sources (Sumitomo) and borofalan (10B). Trials extend to glioma and melanoma. Very few facilities.
How it works
10B captures thermal neutrons and fissions into alpha and lithium particles with ~10 µm range.
- Cellular-level selectivity
- Boron delivery agent limits tumour selectivity
- Few facilities
Latest papers
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Pages like this
not linked directly; found by shared links- IdeaA standing platform for testing new drugs with radiotherapy
Shares Glioma & glioblastoma, Head and neck squamous cell carcinoma.
- InstitutionO'Neal Comprehensive Cancer Center at UAB
Shares Glioma & glioblastoma, Head and neck squamous cell carcinoma.
- IdeaCut the nerve supply to tumours with old drugs
Shares Glioma & glioblastoma, Head and neck squamous cell carcinoma.
- InstitutionQIMR Berghofer Medical Research Institute
Shares Glioma & glioblastoma, Head and neck squamous cell carcinoma.
- TermRe-irradiation
Shares Glioma & glioblastoma, Head and neck squamous cell carcinoma.
- PathwayCancer neuroscience (nerve–tumour signalling)
Shares Glioma & glioblastoma, Head and neck squamous cell carcinoma.
- TermChemoradiation (chemoradiotherapy, CRT)
Shares Glioma & glioblastoma, Head and neck squamous cell carcinoma.
- TargetB7-H3
Shares Glioma & glioblastoma, Head and neck squamous cell carcinoma.