peoplePerson
Timothy J. Ley
Timothy Ley led the first whole-genome sequencing of a cancer, an AML genome, in 2008.
Haematologist-scientist who sequenced the first cancer genome, discovered recurrent DNMT3A and IDH mutations in AML, and defined clonal evolution at relapse.
Role
Lewis T. and Rosalind B. Apple Professor of Oncology
Institution
Specialisms
AML genomicsClonal evolutionDNMT3A
Profiles
| Title | Journal | Year |
|---|---|---|
| DNA sequencing of a cytogenetically normal acute myeloid leukaemia genome | Nature | 2008 |
| DNMT3A mutations in acute myeloid leukemia | New England Journal of Medicine | 2010 |
Pages like this
not linked directly; found by shared links- PersonLi Ding
Shares Siteman Cancer Center, Washington University, Whole-exome & whole-genome sequencing.
- TrialKOMET-001
Shares NPM1 mutation, Acute myeloid leukaemia.
- ProductEnasidenib
Shares IDH1 / IDH2, Acute myeloid leukaemia.
- PersonJohn F. DiPersio
Shares Siteman Cancer Center, Washington University, Acute myeloid leukaemia.
- TrialAGILE
Shares IDH1 / IDH2, Acute myeloid leukaemia.
- ProductOlutasidenib
Shares IDH1 / IDH2, Acute myeloid leukaemia.
- InstitutionNational University Hospital / National University Cancer Institute, Singapore
Shares Whole-exome & whole-genome sequencing, Acute myeloid leukaemia.
- TrialAUGMENT-101
Shares NPM1 mutation, Acute myeloid leukaemia.