Siteman Cancer Center, Washington University
Sequenced the first cancer genome (2008) and leads in neoantigen vaccine science and CIViC.
McDonnell Genome Institute (first whole-genome sequencing of AML), CIViC knowledge base (Griffith), neoantigen prediction (pVACtools), personalised vaccine trials.
- Cancer genomics
- CIViC
- Neoantigen vaccines
Transplant pioneer who developed plerixafor for stem-cell mobilisation and CD7 CAR-T for T-cell leukaemia.
Li Ding is the computational leader of TCGA and CPTAC analyses linking genomes to proteins across cancers.
Co-created CIViC, the open database of what cancer mutations mean, and the pVACtools neoantigen pipeline.
Obi Griffith co-leads CIViC and the open tooling that lets clinicians interpret tumour sequencing.
Showed how smoking-related lung cancers carry ten times the mutations of never-smokers' tumours.
Proposed cancer immunoediting and showed neoantigens are the targets of checkpoint immunotherapy.
Surgeon who has led Siteman since its founding and built it into a top NCI comprehensive centre.
Timothy Ley led the first whole-genome sequencing of a cancer, an AML genome, in 2008.