Kenneth W. Kinzler
Co-discovered APC, the gatekeeper gene of colorectal cancer, and co-led the first cancer genome sequences.
Partner of Vogelstein in identifying APC, mapping colorectal tumour suppressor pathways, and developing digital PCR and Safe-SeqS methods behind liquid biopsy.
| Title | Journal | Year |
|---|---|---|
| Identification of FAP locus genes from chromosome 5q21 | Science | 1991 |
For stage II colon cancer, where most patients are cured by surgery alone, a blood test can identify the minority who benefit from chemotherapy and spare everyone else its side effects. It does not yet prove that treating ctDNA-positive patients improves survival compared with not treating them.
A blood test can find early, treatable cancers in people who feel well, including cancers for which no screening exists. It is not a replacement for mammography or colonoscopy but a possible addition. Larger randomised trials are needed to show benefit outweighs harm.
There are not thousands of cancer genes, and any one patient's tumour is driven by only a few of them. That makes targeted sequencing panels sensible, but because most drivers are lost tumour suppressors, drugs exist for only a minority, which is why the same group turned to early detection.
Pages like this
not linked directly; found by shared links- PersonBert Vogelstein
Shares DETECT-A: a blood test plus PET-CT found treatable cancers in 10,000 women with no symptoms, Lustgarten Foundation, Cancer genome landscapes: about 140 driver genes, and each tumour needs only a handful, DYNAMIC: a blood test safely halved chemotherapy use after surgery for stage II colon cancer.
- PersonEric R. Fearon
Shares Wnt / β-catenin, Colorectal cancer.
- IdeaCheap DNA fragment-pattern blood test as a first sieve before expensive cancer tests
Shares Johns Hopkins Hospital / Sidney Kimmel Comprehensive Cancer Center, Liquid biopsy (ctDNA).
- TermConsensus molecular subtypes (CMS1-4)
Shares Wnt / β-catenin, Colorectal cancer.
- TermLGR5
Shares Wnt / β-catenin, Colorectal cancer.
- Key paperGALAXY: tumour DNA in blood four weeks after bowel cancer surgery predicts relapse tenfold
Shares DYNAMIC: a blood test safely halved chemotherapy use after surgery for stage II colon cancer, Liquid biopsy (ctDNA), Colorectal cancer.
- CompanyDELFI Diagnostics
Shares Johns Hopkins Hospital / Sidney Kimmel Comprehensive Cancer Center, Liquid biopsy (ctDNA).
- InstitutionTawam Hospital
Shares Johns Hopkins Hospital / Sidney Kimmel Comprehensive Cancer Center, Colorectal cancer.